The optimized celecoxibloaded NPs were characterized with regard to their particle size, polydispersity index, zeta potential, morphology and drug content.
The formulation that gave the lowest particle size and polydispersity index and the highest zeta potential was selected and subjected to further studies. Different concentrations of polymers, emulsifier and stabilizers were used to optimize our formulations. Methods: Nanoparticles were prepared using a spontaneous emulsification solvent diffusion method. Background: Our goal was to prepare and evaluate topical ophthalmic formulations containing optimized celecoxib-loaded bioadhesive cationic chitosan or anionic alginate nanoparticles for sustained release of celecoxib.
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